Article
Unexpected MH deaths without exposure to inhalation anesthetics in pediatric patients.
Paediatric anaesthesia - 1 Sept 2013
Brandom Barbara W, Muldoon Sheila M
Abstract excerpt
Children, later found to have ryanodine receptor type one variants (RYR1), died without exposure to inhalation anesthetics. Family members with the same RYR1 variants had contracture tests consistent with susceptibility to malignant hyperthermia or in vitro testing showed increased sensitivity to RYR1 agonist.
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