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Article

Second-order approximations for selection coefficients at polygenic loci.

Journal of mathematical biology - 1 Jan 1990

Hastings A

Abstract excerpt

I determine the second-order approximation for the phenotypic distribution of a quantitative trait, ignoring the effects of epistasis and linkage disequilibrium, conditioned on the presence of a specified genotype at one underlying locus of small effect. I demonstrate that this approximation has an error that is third order in the allelic or genotypic effects, independent of the form of the phenotypic...

Topics

Alleles
Genetics, Population
Humans
Models, Genetic
Models, Theoretical
Phenotype
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2384723
DOI: 10.1007/BF00178330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2384723-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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