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Article

Response of Polygenic Traits Under Stabilizing Selection and Mutation When Loci Have Unequal Effects.

G3 (Bethesda, Md.) - 31 Mar 2015

Jain Kavita, Stephan Wolfgang

Abstract excerpt

We consider an infinitely large population under stabilizing selection and mutation in which the allelic effects determining a polygenic trait vary between loci. We obtain analytical expressions for the stationary genetic variance as a function of the distribution of effects, mutation rate, and selection coefficient. We also study the dynamics of the allele frequencies, focusing on short-term evolution of the...

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Identifiers

PMID: 25834214
DOI: 10.1534/g3.115.017970
PMCID: PMC4478537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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