Article
Cancer heterogeneity--a multifaceted view.
EMBO reports - 1 Aug 2013
De Sousa E Melo Felipe, Vermeulen Louis, Fessler Evelyn, Medema Jan Paul
Abstract excerpt
Cancers of various organs have been categorized into distinct subtypes after increasingly sophisticated taxonomies. Additionally, within a seemingly homogeneous subclass, individual cancers contain diverse tumour cell populations that vary in important cancer-specific traits such as clonogenicity and invasive potential. Differences that exist between and within a given tumour type have hampered significantly both...
Topics
- Cell Differentiation
- Clonal Evolution
- Clone Cells
- Gene Expression
- Genetic Heterogeneity
- Humans
- Mutation
- Neoplasm Proteins
- Neoplasms
- Neoplastic Stem Cells
- Organ Specificity
- Tumor Microenvironment