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Article

The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation.

PloS one - 1 Jan 2013

Sachan Nalani, Mishra Abhinava K, Mutsuddi Mousumi, Mukherjee Ashim

Abstract excerpt

The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation. Upon ligand-induced Notch activation, the Notch intracellular domain (Notch-ICD) is released from the membrane and translocates to the nucleus, where it transduces Notch signals by regulating...

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Identifiers

PMID: 23840889
DOI: 10.1371/journal.pone.0068247
PMCID: PMC3698139

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