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Article

Contrasted Fitness Costs of Docking and Antibacterial Constructs in the EE and EVida3 Strains Validates Two-Phase Anopheles gambiae Genetic Transformation System.

PloS one - 1 Jan 2013

Paton Doug, Underhill Anne, Meredith Janet, Eggleston Paul, Tripet Frederic

Abstract excerpt

The deployment of transgenic mosquitoes carrying genes for refractoriness to malaria has long been seen as a futuristic scenario riddled with technical difficulties. The integration of anti-malarial effector genes and a gene-drive system into the mosquito genome without affecting mosquito fitness is recognized as critical to the success of this malaria control strategy. Here we conducted detailed fitness studies...

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Source

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Identifiers

PMID: 23840679
DOI: 10.1371/journal.pone.0067364
PMCID: PMC3694017

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Source receipt: pubmed, retrieved 7 Sept 2026.

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