Article
Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.
Obesity (Silver Spring, Md.) - 1 Mar 2014
Ketterer Caroline, Heni Martin, Stingl Krunoslav, Tschritter Otto, Linder Katarzyna, Wagner Robert, Machicao Fausto, Häring Hans-Ulrich, Preissl Hubert, Staiger Harald, Fritsche Andreas
Abstract excerpt
OBJECTIVE: The cannabinoid-receptor system is involved in the regulation of food intake. Here, we test whether single nucleotide polymorphisms (SNPs) in CNR2, encoding the cannabinoid-receptor 2, are associated with weight in a cross-sectional cohort. Furthermore, we wanted to investigate if the identified hits influence weight loss during lifestyle intervention; and study a potential involvement of cerebral...
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