Article
Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3).
PloS one - 1 Jan 2013
Diestel Uschi, Resch Marcus, Meinhardt Kathrin, Weiler Sigrid, Hellmann Tina V, Mueller Thomas D, Nickel Joachim, Eichler Jutta, Muller Yves A
Abstract excerpt
The zona pellucida (ZP) domain is present in extracellular proteins such as the zona pellucida proteins and tectorins and participates in the formation of polymeric protein networks. However, the ZP domain also occurs in the cytokine signaling co-receptor transforming growth factor β (TGF-β) receptor type 3 (TGFR-3, also known as betaglycan) where it contributes to cytokine ligand recognition. Currently it is...
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