Article
Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects.
Endocrine - 1 Apr 2014
Saeed Sadia, Bech Paul R, Hafeez Tayyaba, Alam Rabail, Falchi Mario, Ghatei Mohammad A, Bloom Stephen R, Arslan Muhammad, Froguel Philippe
Abstract excerpt
Congenital leptin deficiency, a rare genetic disorder due to a homozygous mutation in the leptin gene (LEP), is accompanied by extreme obesity and hyperphagia. A number of gastrointestinal hormones have been shown to critically regulate food intake but their physiological role in hyperphagic response in congenital leptin deficiency has not been elucidated. This study is the first to evaluate the fasting and...
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