Article
Genetic predisposition to radiation induced sarcoma: possible role for BRCA and p53 mutations.
Breast cancer research and treatment - 1 Jul 2013
Kadouri Luna, Sagi Michal, Goldberg Yael, Lerer Israela, Hamburger Tamar, Peretz Tamar
Abstract excerpt
The estimated incidence of radiation-associated sarcoma (RAS) is 0.03-0.2 % in 5 years post treatment. Most cancer predisposing genes are involved in DNA repair; therefore, elevated RAS risk in these patients is plausible. Cases of angiosarcoma post breast cancer treatment were reported in BRCA1 and BRCA2 carriers. We report the genetic evaluation of seven cases with suspected RAS from patients counseled in our...
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