Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis.

Acta biochimica et biophysica Sinica - 1 Sept 2013

Liu Shiguo, Fang Yue, Shen Huiling, Xu Wenlin, Li Hao

Abstract excerpt

Recent studies have shown that microRNA-21 (miR-21) contributes to tumor resistance to chemotherapy. Interestingly, we have found that berberine could inhibit miR-21 expression in several cancer cell lines. In this study, we investigated whether berberine could modulate the sensitivity of ovarian cancer cells to cisplatin and explored the mechanism. The cisplatin-resistant SKOV3 cells that were incubated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Drug Synergism

Share to Oligonucleotides, Antisense

Share to Ovarian Neoplasms

Share to RNA-Binding Proteins

Share to RNA Interference

Source

Identifiers

PMID: 23824073
DOI: 10.1093/abbs/gmt075

Genes

PDCD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis.PMID 23824073Read ↗

Berberine regulates the microRNA‑21‑ITGΒ4‑PDCD4 axis and inhibits colon cancer viabilitySemantic proximity Read ↗

Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberineSemantic proximity Read ↗

Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cellsSemantic proximity Read ↗

Molecular mechanisms of cisplatin resistance in ovarian cancerSemantic proximity Read ↗

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer CellsSemantic proximity Read ↗

Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cellsSemantic proximity Read ↗

Cisplatin in Ovarian Cancer Treatment—Known Limitations in Therapy Force New SolutionsSemantic proximity Read ↗

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repairSemantic proximity Read ↗

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancerSemantic proximity Read ↗

Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell linesSemantic proximity Read ↗

MicroRNA-21 regulates the sensitivity to cisplatin in a human osteosarcoma cell lineSemantic proximity Read ↗

Melatonin Sensitize the Ovarian Cancer Cells to Cisplatin through suppression of PI3K/Akt pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.