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Article

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance.

Journal of biomedical science - 27 Jun 2013

Chang Kwang-Yu, Tsai Shan-Yin, Chen Shang-Hung, Tsou Hsiao-Hui, Yen Chia-Jui, Liu Ko-Jiunn, Fang Hsun-Lang, Wu Hung-Chang, Chuang Bin-Fay, Chou Shao-Wen, Tang Careen K, Liu Shyun-Yeu, Lu Pei-Jung, Yen Ching-Yu, Chang Jang-Yang

Abstract excerpt

BACKGROUND: Dysregulated epidermal growth factor receptor (EGFR)-phosphoinositide-3-kinase (PI3K)-AKT signaling is considered pivotal for oral cancer, and the pathway is a potential candidate for therapeutic targeting. RESULTS: A total of 108 archival samples which were from surgically resected oral cancer were examined. Immunohistochemical staining showed the protein expression of membranous wild-type EGFR and...

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Identifiers

PMID: 23806066
DOI: 10.1186/1423-0127-20-43
PMCID: PMC3710269

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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