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Cryopreservation Causes Genetic and Epigenetic Changes in Zebrafish Genital Ridges

21 Jun 2013

Abstract excerpt

Cryopreservation is an important tool routinely employed in Assisted Reproduction Technologies (ARTs) and germplasm banking. For several years, the assessment of global DNA fragmentation seemed to be enough to ensure the integrity of genetic material. However, cryopreservation can produce molecular alterations in key genes and transcripts undetectable by traditional assays, such modifications could interfere with...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 23805321
DOI: 10.1371/journal.pone.0067614

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