Article
Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish.
Developmental biology - 1 Sept 2013
Xia Zhidan, Tong Xiangjun, Liang Fang, Zhang Yihan, Kuok Chikin, Zhang Yingla, Liu Xinxing, Zhu Zuoyan, Lin Shuo, Zhang Bo
Abstract excerpt
Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due to the hypogenesis of cranial neural crest cells (NCCs). The derivatives of cranial NCCs,...
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