Involvement of mi RNA ‐29a in epigenetic regulation of transforming growth factor‐β‐induced epithelial–mesenchymal transition in hepatocellular carcinoma

Abstract excerpt

AIM: Epithelial-mesenchymal transition (EMT) is a crucial process during cancer invasion and metastasis, which is accompanied by the suppressed expression of E-cadherin initiated by stimuli such as transforming growth factor (TGF)-β. Recent studies have shown that the epigenetic regulation of E-cadherin could be an alternate mechanism of EMT induction in hepatocellular carcinoma (HCC). miRNA-29a (miR-29a) is...

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