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Reconstructing a flavodoxin oxidoreductase with early amino acids.

International journal of molecular sciences - 19 Jun 2013

Lu Ming-Feng, Ji Hong-Fang, Li Ting-Xuan, Kang Shou-Kai, Zhang Yue-Jie, Zheng Jue-Fei, Tian Tian, Jia Xi-Shuai, Lin Xing-Ming, Zhang Hong-Yu

Abstract excerpt

Primitive proteins are proposed to have utilized organic cofactors more frequently than transition metals in redox reactions. Thus, an experimental validation on whether a protein constituted solely by early amino acids and an organic cofactor can perform electron transfer activity is an urgent challenge. In this paper, by substituting "late amino acids (C, F, M, T, W, and Y)" with "early amino acids (A, L, and...

Topics

Amino Acids
Circular Dichroism
Fluorescence
Kinetics
Megasphaera
Mutagenesis
Mutant Proteins
Mutation
NADH, NADPH Oxidoreductases
Oxidation-Reduction
Recombinant Proteins

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Identifiers

PMID: 23783279
DOI: 10.3390/ijms140612843
PMCID: PMC3709815

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