Article
Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors.
PloS one - 1 Jan 2013
Weber Jan, Rose Justine D, Vazquez Ana C, Winner Dane, Margot Nicolas, McColl Damian J, Miller Michael D, Quiñones-Mateu Miguel E
Abstract excerpt
Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses). However, to date, many of the patients on INSTI-based treatment regimes, such as raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) are infected with multidrug-resistant HIV-1 strains. Here we analyzed the effect of...
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