Article
Native American admixture in the Quebec founder population.
PloS one - 1 Jan 2013
Moreau Claudia, Lefebvre Jean-François, Jomphe Michèle, Bhérer Claude, Ruiz-Linares Andres, Vézina Hélène, Roy-Gagnon Marie-Hélène, Labuda Damian
Abstract excerpt
For years, studies of founder populations and genetic isolates represented the mainstream of genetic mapping in the effort to target genetic defects causing Mendelian disorders. The genetic homogeneity of such populations as well as relatively homogeneous environmental exposures were also seen as primary advantages in studies of genetic susceptibility loci that underlie complex diseases. European colonization of...
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