Article
Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case-control study of contralateral breast cancer risk in the WECARE Study.
Cancer causes & control : CCC - 1 Aug 2013
Brooks Jennifer D, Teraoka Sharon N, Bernstein Leslie, Mellemkjær Lene, Malone Kathleen E, Lynch Charles F, Haile Robert W, Concannon Patrick, Reiner Anne S, Duggan David J, Schiermeyer Katherine, Bernstein Jonine L, Figueiredo Jane C
Abstract excerpt
PURPOSE: Women who receive chemotherapy for a first primary breast cancer have been observed to have a reduced risk of contralateral breast cancer (CBC), however, whether the genetic profile of a patient modifies this protective effect is currently not understood. The purpose of this study is to investigate the impact of germline genetic variation in genes coding for drug metabolizing enzymes, transporters, and...
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