Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.

doi:10.1007/s10549-010-1285-1

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Article

Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.

Breast cancer research and treatment - 1 Jun 2011

Figueiredo Jane C, Brooks Jennifer D, Conti David V, Poynter Jenny N, Teraoka Sharon N, Malone Kathleen E, Bernstein Leslie, Lee Won D, Duggan David J, Siniard Ashley, Concannon Patrick, Capanu Marinela, Lynch Charles F, Olsen Jørgen H, Haile Robert W, Bernstein Jonine L

Abstract excerpt

Rare deleterious mutations in BRCA1 and BRCA2 are associated with an elevated risk of breast and ovarian cancer. Whether or not common variants in these genes are independently associated with risk of breast cancer remains unclear. In this study, we included 632 Caucasian women with asynchronous contralateral breast cancer (CBC, cases) and 1,221 women with unilateral breast cancer (UBC, controls) from the WECARE...

Topics

Adult
Aged
Breast Neoplasms
Chromatography, High Pressure Liquid
Female
Gene Frequency
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Middle Aged

Mutation

Polymorphism, Single Nucleotide

Risk

Sequence Analysis, DNA

Sequence Deletion

Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 21161372
DOI: 10.1007/s10549-010-1285-1
PMCID: PMC3234998

Genes

BRCA1
BRCA2
MAF
UBC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.PMID 21161372Read ↗

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