Article
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Noise & health - 1 Jan 2000
Hu Feifei, Li Xin, Li Xiuting, Wang Meilin, Chu Haiyan, Liu Kai, Zhang Hengdong, Zhang Zhengdong, Zhu Baoli
Abstract excerpt
DNA methyltransferase 1 (DNMT1) plays a crucial role in maintaining of methylation and chromatin stability. And mutations in DNMT1 can induce one form of neurodegenerative diseases with dementia and sensorineural hearing loss. To assess whether single nucleotide polymorphisms (SNPs) or haplotypes of DNMT1 are related to noise-induced hearing loss (NIHL) in a Chinese population, we genotyped three functional...
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