Article
On the structural affinity of macromolecules with different biological properties: molecular dynamics simulations of a series of TEM-1 mutants.
Biochemical and biophysical research communications - 12 Jul 2013
Giampaolo Alessia Di, Mazza Fernando, Daidone Isabella, Amicosante Gianfranco, Perilli Mariagrazia, Aschi Massimiliano
Abstract excerpt
Molecular Dynamics simulations have been carried out in order to provide a molecular rationalization of the biological and thermodynamic differences observed for a class of TEM β-lactamases. In particular we have considered the TEM-1(wt), the single point mutants TEM-40 and TEM-19 representative of IRT and ESBL classes respectively, and TEM-1 mutant M182T, TEM-32 and TEM-20 which differ from the first three for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.