Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection

Abstract excerpt

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diagnosis and treatment of tuberculosis
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology