Molecular genetic aspects of weight regulation.

Abstract excerpt

BACKGROUND: Family and twin studies have empirically revealed a 40% to 70% heritability of body-mass index, yet only a few hereditary factors have been identified to date that increase the risk of being overweight. METHODS: We present the current state of molecular genetic research on obesity with a selective review of the literature. RESULTS: A number of monogenic recessive mutations causing obesity have been...

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