Genetic contributors to obesity.

Abstract excerpt

Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%. More than 244 genes have been found to strongly affect adiposity when overexpressed or deleted in mice. These genes can be considered in four broad categories: regulation of food intake by molecular signalling in the hypothalamus and hindbrain by signals originating in adipose...

Topics

• Adipose Tissue
• Animals
• Energy Metabolism
• Genetic Predisposition to Disease
• Humans
• Hypothalamus
• Leptin
• Mice
• Obesity
• Sensitivity and Specificity