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Article

Post-GWAS: where next? More samples, more SNPs or more biology?

Heredity - 1 Jan 2014

Marjoram P, Zubair A, Nuzhdin S V

Abstract excerpt

The power of genome-wide association studies (GWAS) rests on several foundations: (i) there is a significant amount of additive genetic variation, (ii) individual causal polymorphisms often have sizable effects and (iii) they segregate at moderate-to-intermediate frequencies, or will be effectively 'tagged' by polymorphisms that do. Each of these assumptions has recently been questioned. (i) Why should genetic...

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Identifiers

PMID: 23759726
DOI: 10.1038/hdy.2013.52
PMCID: PMC3860164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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