Inference of genetic architecture from chromosome partitioning analyses is sensitive to genome variation, sample size, heritability and effect size distribution.

Abstract excerpt

Genomewide association studies have contributed immensely to our understanding of the genetic basis of complex traits. One major conclusion arising from these studies is that most traits are controlled by many loci of small effect, confirming the infinitesimal model of quantitative genetics. A popular approach to test for polygenic architecture involves so-called "chromosome partitioning" where phenotypic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Birds
• Share to Computer Simulation
• Share to Genetic Association Studies