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Article

Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy.

Tissue engineering. Part C, Methods - 1 Feb 2014

Wu Ling, Gonzalez Stephanie, Shah Saumya, Kyupelyan Levon, Petrigliano Frank A, McAllister David R, Adams John S, Karperien Marcel, Tuan Tai-Lan, Benya Paul D, Evseenko Denis

Abstract excerpt

Cartilage injury represents one of the most significant clinical conditions. Implantation of expanded autologous chondrocytes from noninjured compartments of the joint is a typical strategy for repairing cartilage. However, two-dimensional culture causes dedifferentiation of chondrocytes, making them functionally inferior for cartilage repair. We hypothesized that functional exclusion of dedifferentiated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23758619
DOI: 10.1089/ten.TEC.2013.0056
PMCID: PMC3910562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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