Spontaneous loss of heterozygosity leading to homozygous R132H in a patient-derived IDH1 mutant cell line

Abstract excerpt

Dear Editor, We report a novel follow-up observation pertaining to “An in vivo patient-derived model of endogenous IDH1-mutant glioma,” which was recently published in Neuro-Oncology.1 Since publication, we have observed the gradual and repeated loss of the wild-type IDH1 allele in vitro with retention of the mutant allele. Sequencing of IDH1 exon 4 from 3 independent late passage cultures showed homozygosity for...

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