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Autophagy Is Involved in Nutritional Stress Response and Differentiation in Trypanosoma cruzi

26 Nov 2007

Abstract excerpt

Autophagy is the major mechanism used by eukaryotic cells to degrade and recycle proteins and organelles. Bioinformatics analysis of the genome of the protozoan parasite Trypanosoma cruzi revealed the presence of all components of the Atg8 conjugation system, whereas Atg12, Atg5, and Atg10 as the major components of the Atg12 pathway could not be identified. The two TcATG4 (autophagin) homologs present in the...

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PMID: 18039653
DOI: 10.1074/jbc.m708474200

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