Article
Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-β1.
Pediatric nephrology (Berlin, Germany) - 1 Sept 2013
Giani Marisa, Mastrangelo Antonio, Villa Roberta, Turolo Stefano, Marra Giuseppina, Tirelli Amedea Silvia, Hopfer Helmut, Edefonti Alberto
Abstract excerpt
BACKGROUND: Alport syndrome (AS) is a progressive hereditary glomerular disease. Recent data indicate that aldosterone promotes fibrosis mediated by the transforming growth factor-β1 (TGF-β1) pathway, which may worsen proteinuria. Spironolactone (SP) antagonizes aldosterone and this study aimed t...
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