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Article

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

The Journal of biological chemistry - 19 Jul 2013

Chen Pei-Chun, Olson Erik M, Zhou Qing, Kryukova Yelena, Sampson Heidi M, Thomas David Y, Shyng Show-Ling

Abstract excerpt

ATP-sensitive potassium (KATP) channels consisting of sulfonylurea receptor 1 (SUR1) and the potassium channel Kir6.2 play a key role in insulin secretion by coupling metabolic signals to β-cell membrane potential. Mutations in SUR1 and Kir6.2 that impair channel trafficking to the cell surface lead to loss of channel function and congenital hyperinsulinism. We report that carbamazepine, an anticonvulsant,...

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Identifiers

PMID: 23744072
DOI: 10.1074/jbc.M113.470948
PMCID: PMC3774364

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