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Article

Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers.

British journal of clinical pharmacology - 1 Jan 2014

Markert Christoph, Schweizer Yvonne, Hellwig Regina, Wirsching Theresia, Riedel Klaus-Dieter, Burhenne Juergen, Weiss Johanna, Mikus Gerd, Haefeli Walter E

Abstract excerpt

AIMS: The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion-transporting polypeptide (OATP) 1B1 inhibitor clarithromycin on the pharmacokinetics of bosentan. We also aimed to evaluate the impact of CYP2C9 and SLCO1B1 (encoding for OATP1B1) genotypes and their combination. METHODS: We assessed the effect of the OATP and CYP3A inhibitor clarithromycin on bosentan...

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Identifiers

PMID: 23738582
DOI: 10.1111/bcp.12177
PMCID: PMC3895355

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Source receipt: pubmed, retrieved 7 Sept 2026.

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