Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers.

British journal of clinical pharmacology - 1 Jan 2014

Markert Christoph, Schweizer Yvonne, Hellwig Regina, Wirsching Theresia, Riedel Klaus-Dieter, Burhenne Juergen, Weiss Johanna, Mikus Gerd, Haefeli Walter E

Abstract excerpt

AIMS: The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion-transporting polypeptide (OATP) 1B1 inhibitor clarithromycin on the pharmacokinetics of bosentan. We also aimed to evaluate the impact of CYP2C9 and SLCO1B1 (encoding for OATP1B1) genotypes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Anxiety Agents
Share to Clarithromycin
Share to Cytochrome P-450 CYP3A Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Healthy Volunteers

Share to Liver-Specific Organic Anion Transporter 1

Share to Midazolam

Share to Organic Anion Transporters

Source

Open in PubMed Open full text

Identifiers

PMID: 23738582
DOI: 10.1111/bcp.12177
PMCID: PMC3895355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23738582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers.PMID 23738582Read ↗

Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis.Semantic proximity Read ↗

Inhibition of cytochrome P450 3A by clarithromycin uniformly affects the pharmacokinetics and pharmacodynamics of oxycodone in young and elderly volunteers.Semantic proximity Read ↗

Pharmacokinetic Drug-Drug Interactions of DA-8010 with Clarithromycin or Rifampicin: Influence of CYP2D6 Phenotype on the Extent of These Interactions.Semantic proximity Read ↗

Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes.Semantic proximity Read ↗

Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing.Semantic proximity Read ↗

Effect of breviscapine on CYP3A metabolic activity in healthy volunteers.Semantic proximity Read ↗

Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries.Semantic proximity Read ↗

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.Semantic proximity Read ↗

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.Semantic proximity Read ↗

Effects of erythromycin on voriconazole pharmacokinetics and association with CYP2C19 polymorphism.Semantic proximity Read ↗

Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.Semantic proximity Read ↗

Effects of Age, Gender, and Race/Ethnicity on the Pharmacokinetics of Posaconazole in Healthy VolunteersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.