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Article

ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera.

Thrombosis research - 1 Jul 2013

Panova-Noeva Marina, Marchetti Marina, Russo Laura, Tartari Carmen J, Leuzzi Anna, Finazzi Guido, Rambaldi Alessandro, ten Cate Hugo, Falanga Anna

Abstract excerpt

INTRODUCTION: Essential Thrombocythemia (ET) and Polycythemia Vera (PV) patients are characterized by an increased rate of thrombotic complications and by several abnormalities of platelets, more pronounced in JAK2V617F positive patients. The aim of this study was to characterize the platelet aggregation as well as the platelet procoagulant potential induced by several different agonists in ET and PV patients....

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PMID: 23735588
DOI: 10.1016/j.thromres.2013.05.003

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