Article
Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera.
American journal of hematology - 1 Apr 2011
Panova-Noeva Marina, Marchetti Marina, Spronk Henri Maria, Russo Laura, Diani Erika, Finazzi Guido, Finazzi Good, Salmoiraghi Silvia, Rambaldi Alessandro, Rambaldi Aueesandrd, Barbui Tiziano, Barbui Titiano, Ten Cate Hugo, Ten Cate Huao, Falanga Anna
Abstract excerpt
The platelet contribution to the thrombophilic state of patients with myeloproliferative neoplasms (MPNs), i.e., essential thrombocythemia (ET) and polycythemia vera (PV), remains uncertain. In this study we aimed to characterize the thrombin generation (TG) potential expressed by platelets from these subjects, compare it to normal platelets, and identify what factors might be responsible for platelet TG. In a...
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