Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer.

doi:10.1371/journal.pone.0065121

Article

Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer.

PloS one - 1 Jan 2013

Zhang Wang, Pal Sumanta K, Liu Xueli, Yang Chunmei, Allahabadi Sachin, Bhanji Shaira, Figlin Robert A, Yu Hua, Reckamp Karen L

Abstract excerpt

BACKGROUND: This study aimed to understand the role of myeloid cell clusters in uninvolved regional lymph nodes from early stage non-small cell lung cancer patients. METHODS: Uninvolved regional lymph node sections from 67 patients with stage I-III resected non-small cell lung cancer were immunostained to detect myeloid clusters, STAT3 activity and occult metastasis. Anthracosis intensity, myeloid cluster...

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Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer.

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