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Article

Immunologic and clinical aspects of natural killer cells in human leukemia.

Natural immunity and cell growth regulation - 1 Jan 1990

Lotzová E, Savary C A, Pollock R E, Fuchshuber P

Abstract excerpt

We have studied peripheral-blood, splenic and bone marrow natural killer (NK) activity in patients with leukemia. These studies demonstrated that leukemic patients displayed defective NK activity in all of these tissues. However, NK defect could be corrected by culture of effector cells with interleukin-2 (IL-2). The phenotypic analysis of IL-2 cultures showed clearly the heterogeneity of lymphocyte subsets. The...

Topics

Bone Marrow Cells
Cytotoxicity, Immunologic
Humans
Interleukin-2
Killer Cells, Natural
Leukemia
Phenotype
Spleen

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2370877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2370877-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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