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Article

Genetic association and gene expression profiles of TGFB1 and the contribution of TGFB1 to otosclerosis susceptibility.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2013

Priyadarshi Saurabh, Ray Chinmay Sundar, Panda Khirod Chandra, Desai Ashim, Nayak Soumya Ranjan, Biswal Narayan Chandra, Ramchander Puppala Venkat

Abstract excerpt

Otosclerosis (OTSC) is a common form of acquired hearing loss resulting from disturbed bone remodeling in the otic capsule of the middle ear. Transforming growth factor-beta1 (TGFB1) produced by osteoblasts is the most abundant growth factor in human bone. Previous studies have shown the contribution of single-nucleotide polymorphisms (SNPs) in TGFB1 toward the risk of developing OTSC in some ethnic populations....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23703862
DOI: 10.1002/jbmr.1991

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic association and gene expression profiles of TGFB1 and the contribution of TGFB1 to otosclerosis susceptibility.PMID 23703862Read ↗

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