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Article

Mapping and exome sequencing identifies a mutation in the IARS gene as the cause of hereditary perinatal weak calf syndrome.

PloS one - 1 Jan 2013

Hirano Takashi, Kobayashi Naohiko, Matsuhashi Tamako, Watanabe Daisaku, Watanabe Toshio, Takasuga Akiko, Sugimoto Mayumi, Sugimoto Yoshikazu

Abstract excerpt

We identified an IARS (isoleucyl-tRNA synthetase) c.235G>C (p.Val79Leu) substitution as the causative mutation for neonatal weakness with intrauterine growth retardation (perinatal weak calf syndrome). In Japanese Black cattle, the syndrome was frequently found in calves sired by Bull A. Hence, we employed homozygosity mapping and linkage analysis. In order to identify the perinatal weak calf syndrome locus in a...

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PMID: 23700453
DOI: 10.1371/journal.pone.0064036
PMCID: PMC3660308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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