Article
Carrier rate of the c.235G>C mutation in the bovine isoleucyl-tRNA synthetase (IARS) gene of Japanese Black cows at Kagoshima prefecture, Japan, and analysis of the metabolic profiling and reproductive performance of heterozygous cows.
The Journal of veterinary medical science - 5 Mar 2021
Islam Md Shafiqul, Shinya Urara, Takagi Mitsuhiro, Akahoshi Takao, Yabuki Akira, Pervin Shahnaj, Rakib Tofazzal Md, Rahman Mohammad Mahbubur, Tacharina Martia Rani, Yamato Osamu
Abstract excerpt
Bovine isoleucyl-tRNA synthetase (IARS) disorder, a major cause of weak calf syndrome, is caused by a homozygous missense (c.235G>C) mutation in the bovine IARS gene of Japanese Black (JB) cattle, which was identified in 2013. However, the extent to which the carrier rate has changed at Kagoshima prefecture, Japan, and whether the carrier status is associated with any clinical or reproductive problems, have yet...
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