Dosage-sensitivity of imprinted genes expressed in the brain: 15q11–q13 and neuropsychiatric illness

Abstract excerpt

Imprinted genes, those genes subject to parent-of-origin-specific epigenetic marking resulting in monoallelic parent-specific expression, are sensitive to subtle changes in expression dosage. This has been illustrated in a number of experimental models and the fact that both decreased (or complete loss) and increased imprinted gene expression can lead to human diseases. In the present paper, we discuss the...

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