Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells

21 May 2013

Abstract excerpt

The differentiated state of mature cells of adult organisms is achieved and maintained through the epigenetic regulation of gene expression, which consists of several mechanisms including DNA methylation. The advent of induced pluripotent stem cell technology enabled the conversion of adult cells into any other cell type passing through a stable pluripotency state. However, indefinite pluripotency is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Pancreatic function and diabetes
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23696663
DOI: 10.1073/pnas.1220637110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cellsPMID 23696663Read ↗

Phenotype switching through epigenetic conversion.Semantic proximity Read ↗

Reprogramming of Pig Dermal Fibroblast into Insulin Secreting Cells by a Brief Exposure to 5-aza-cytidineSemantic proximity Read ↗

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells FateSemantic proximity Read ↗

5-Azacytidine makes human preadipocytes able to differentiate into mesoderm-derived cell lineages.Semantic proximity Read ↗

Direct reprogramming of human fibroblasts into insulin-producing cells by transcription factorsSemantic proximity Read ↗

Reprogramming mouse embryo fibroblasts to functional islets without genetic manipulation.Semantic proximity Read ↗

Differentiation protocol for generating functional pancreatic β cells from human pluripotent stem cellsSemantic proximity Read ↗

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta CellsSemantic proximity Read ↗

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cellsSemantic proximity Read ↗

An overview on small molecule-induced differentiation of mesenchymal stem cells into beta cells for diabetic therapySemantic proximity Read ↗

Differentiation of human multipotent dermal fibroblasts into islet-like cell clustersSemantic proximity Read ↗

5-Aza Exposure Improves Reprogramming Process Through Embryoid Body Formation in Human Gingival Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.