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Article

Expression of microRNA‐184 in keratinocytes represses argonaute 2

21 May 2013

Abstract excerpt

Interleukin-22 (IL-22) is a proinflammatory cytokine that has been associated with the pathogenesis of inflammatory skin disorders. However, the impact of IL-22 on microRNA (miRNA) expression in epidermal keratinocytes is unknown. Here we show that IL-22 induces miR-184 in reconstituted human epidermis (RHE) and in the HaCaT keratinocyte cell line. Exposure to IL-22 increased miR-184 expression 8- and 15-fold in...

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PMID: 23696368
DOI: 10.1002/jcp.24401

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