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Article

Complicated hereditary spastic paraparesis with cerebral white matter lesions.

American journal of medical genetics - 1 Jun 1990

Gutmann D H, Fischbeck K H, Kamholz J

Abstract excerpt

A family is described with 5 males in a single generation affected with a previously undescribed complicated form of hereditary spastic paraparesis (HSP). The disease is characterized by speech difficulties, lower limb spasticity and hyper-reflexia, mental retardation, cerebellar ataxia, and tremor. The disease starts in the first decade of life and progresses for 3 to 6 years before stabilizing. Magnetic...

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Identifiers

PMID: 2368815
DOI: 10.1002/ajmg.1320360222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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