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Article

Hereditary diffuse leukoencephalopathy with spheroids characterized by spastic hemiplegia preceding mental impairment.

Internal medicine (Tokyo, Japan) - 1 Jan 2014

Kitani-Morii Fukiko, Kasai Takashi, Tomonaga Kei, Saito Kozo, Mizuta Ikuko, Yoshioka Akira, Nakagawa Masanori, Mizuno Toshiki

Abstract excerpt

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a young-adult-onset autosomal dominant white matter disease characterized by progressive cognitive dysfunction. We herein report the case of a 20-year-old woman who developed spastic hemiplegia. Brain magnetic resonance imaging revealed increased bilateral T2 signal intensity and bright diffusion-weighted imaging signals with a low apparent diffusion...

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PMID: 24930661
DOI: 10.2169/internalmedicine.53.1932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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