Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Raised Intraocular Pressure as a Potential Risk Factor for Visual Loss in Leber Hereditary Optic Neuropathy

7 May 2013

Abstract excerpt

Leber Hereditary Optic Neuropathy (LHON) is an important cause of inherited mitochondrial blindness among young adults. The majority of patients carry one of three mitochondrial DNA (mtDNA) point mutations: m.3460G>A, m.11778G>A and m.14484T>C, all of which affect critical complex I subunits of the mitochondrial respiratory chain. LHON is characterised by marked incomplete penetrance, clearly implying that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Ocular Toxicity
Share to Mitochondrial Function and Pathology
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23667621
DOI: 10.1371/journal.pone.0063446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Raised Intraocular Pressure as a Potential Risk Factor for Visual Loss in Leber Hereditary Optic NeuropathyPMID 23667621Read ↗

Leber hereditary optic neuropathy.Semantic proximity Read ↗

Leber hereditary optic neuropathy: mitochondrial mutations and degeneration of the optic nerve.Semantic proximity Read ↗

[Sudden blindness: consider Leber's hereditary optic neuropathy].Semantic proximity Read ↗

Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve.Semantic proximity Read ↗

Clinical, biochemical and molecular genetic features of Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Leber hereditary optic neuropathy: bridging the translational gap.Semantic proximity Read ↗

Leber hereditary optic neuropathy: how do mitochondrial DNA mutations cause degeneration of the optic nerve?Semantic proximity Read ↗

Leber hereditary optic neuropathy in Australia.Semantic proximity Read ↗

The epidemiology and mutation types of Leber's hereditary optic neuropathy in Thailand.Semantic proximity Read ↗

Leber's hereditary optic neuropathy, intellectual disability and epilepsy presenting with variable penetrance associated to the m.3460G >A mutation and a heteroplasmic expansion of the microsatellite in MTRNR1 gene - case report.Semantic proximity Read ↗

Leber hereditary optic neuropathy - historical report in comparison with the current knowledge.Semantic proximity Read ↗

Gene–environment interactions in Leber hereditary optic neuropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.