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Article

Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure.

Reproductive biomedicine online - 1 Jul 2013

Zhao Zhiyi, Wei Deying, Mu Yulan, Qin Yingying, Li Guangyu, Cui Linlin, Chen Zi-Jiang

Abstract excerpt

P27 and SKP2, a major regulator of P27, play a crucial role in ovarian function in mice. Both P27-deficient and SKP2-deficient female mice develop premature ovarian failure (POF). The coding regions of SKP2 and P27 were examined in 200 Chinese women with POF and 200 control volunteers. This study is the first to investigate SKP2 in POF. No plausible pathogenic mutations were detected. The results suggest that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23665265
DOI: 10.1016/j.rbmo.2013.03.017

Genes

SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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