Article
Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma.
Radiation oncology (London, England) - 11 May 2013
Xie Xiaoxue, Wang Hui, Jin Hekun, Ouyang Shuyu, Zhou Jumei, Hu Jun, Xi Xuping, Luo Junming, Zhang Yingying, Hu Bingqiang
Abstract excerpt
BACKGROUND: Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with the ability of the gene to induce cell apoptosis. The PI3K/Akt pathway plays an essential role in the transcriptional activation function of p53, and is an important factor in radiotherapy resistance. The present study was designed to evaluate the prediction of response to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.