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Article

Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology.

PloS one - 1 Jan 2013

Carlin Jesselea, George Robert, Reyes Teresa M

Abstract excerpt

Maternal consumption of a high fat diet during pregnancy increases the offspring risk for obesity. Using a mouse model, we have previously shown that maternal consumption of a high fat (60%) diet leads to global and gene specific decreases in DNA methylation in the brain of the offspring. The present experiments were designed to attempt to reverse this DNA hypomethylation through supplementation of the maternal...

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Identifiers

PMID: 23658839
DOI: 10.1371/journal.pone.0063549
PMCID: PMC3642194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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