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Article

Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.

The EMBO journal - 29 May 2013

Rus Florentina, Flatt Thomas, Tong Mei, Aggarwal Kamna, Okuda Kendi, Kleino Anni, Yates Elisabeth, Tatar Marc, Silverman Neal

Abstract excerpt

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. We identify a...

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Identifiers

PMID: 23652443
DOI: 10.1038/emboj.2013.100
PMCID: PMC3671248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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